Define the claim
Ask whether a source describes two substances used together, tests an added benefit, or establishes a restriction. Those are different claims. AxonRep keeps them separate instead of reducing them to a single compatibility score.
Check the comparison
A combination needs a relevant comparison before a result can support an added-benefit claim. A report that includes combination use does not by itself establish that the combination works better than either component alone.
Read the example in context
The BPC-157 knee report includes four patients who received BPC-157 plus TB4. This small, uncontrolled subgroup cannot establish added benefit or combination safety. The extracted record keeps that limitation beside the reported outcome.
Identify the actual preparation
Check the substance names, formulation, route, population, and duration. Do not assume a blend or a similarly named product matches the preparation in a publication. Follow-up time also does not define a repeatable dosing cycle.
Understand the evidence labels
“Label guidance” refers to cited prescribing information. “Human study” identifies the setting, not the strength of the design. “Preclinical” identifies cell or animal research. “Not established” and “Evidence gap” mean the selected sources do not support a conclusion or supply a needed detail.
Read an avoid statement precisely
A label restriction, a reported adverse event, a theoretical concern, and an unreviewed combination should not be treated as equivalent. Read the reason and source attached to the statement. An empty avoid list is not evidence that every pairing is safe.
Return to the original question
Before interpreting a pairing, be able to identify what was tested, against what comparator, in whom, for how long, and with what safety reporting. If one of those is missing, retain the uncertainty rather than converting the finding into a personal protocol.
Editorial draft · Source-linked example · Clinical/editorial review pending
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